Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
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ABSTRACT:
SUBMITTER: Gross T
PROVIDER: S-EPMC7349490 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
Gross Tilman T Wack Gesine G Syhr Katharina M J KMJ Tolmachova Tanya T Seabra Miguel C MC Geisslinger Gerd G Niederberger Ellen E Schmidtko Achim A Kallenborn-Gerhardt Wiebke W
Cells 20200618 6
Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing; however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dors ...[more]
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