Ontology highlight
ABSTRACT:
SUBMITTER: Toupance S
PROVIDER: S-EPMC7349705 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Toupance Simon S Stathopoulou Maria G MG Petrelis Alexandros M AM Gorenjak Vesna V Labat Carlos C Lai Tsung-Po TP Visvikis-Siest Sophie S Benetos Athanase A
Cells 20200531 6
Short leukocyte telomere length (LTL) is associated with atherosclerotic cardiovascular disease (ASCVD). Mendelian randomisation studies, using single nucleotide polymorphisms (SNPs) associated with short LTL, infer a causal role of LTL in ASCVD. Recent results, using the blood-and-muscle model, indicate that higher early life LTL attrition, as estimated by the ratio between LTL and skeletal muscle telomere length (MTL), rather than short LTL at conception, as estimated by MTL, should be respons ...[more]