Ontology highlight
ABSTRACT:
SUBMITTER: Munz C
PROVIDER: S-EPMC7349826 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cells 20200604 6
The Epstein-Barr virus (EBV) is associated with lymphomas and carcinomas. For some of these, the adoptive transfer of EBV specific T cells has been therapeutically explored, with clinical success. In order to avoid naturally occurring EBV specific autologous T cell selection from every patient, the transgenic expression of latent and early lytic viral antigen specific T cell receptors (TCRs) to redirect T cells, to target the respective tumors, is being developed. Recent evidence suggests that n ...[more]