Ontology highlight
ABSTRACT:
SUBMITTER: Gaber A
PROVIDER: S-EPMC7349879 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gaber Aljaž A Lenarčič Brigita B Pavšič Miha M
Cells 20200531 6
EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent discoveries of its role in signaling with implications in cell proliferation and differentiation, and findings contradicting a direct role in mediating adhesion contacts, we provide a comprehensive and updated overview on the available structural data on EpCAM and interpret it in the light of recent reports on its function. First, we describe th ...[more]