Ontology highlight
ABSTRACT:
SUBMITTER: Vega-Benedetti AF
PROVIDER: S-EPMC7349989 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Vega-Benedetti Ana Florencia AF Loi Eleonora E Moi Loredana L Orrù Sandra S Ziranu Pina P Pretta Andrea A Lai Eleonora E Puzzoni Marco M Ciccone Letizia L Casadei-Gardini Andrea A Cabras Francesco F Fortunato Federica F Restivo Angelo A Zorcolo Luigi L Scartozzi Mario M Zavattari Patrizia P
International journal of molecular sciences 20200624 12
Colorectal cancer (CRC) is a major cause of cancer mortality. Early diagnosis is relevant for its prevention and treatment. Since DNA methylation alterations are early events in tumourigenesis and can be detected in cell-free DNA, they represent promising biomarkers for early CRC diagnosis through non-invasive methods. In our previous work, we identified 74 early altered CpG islands (CGIs) associated with genes involved in cell cross-talking and cell signalling pathways. The aim of this work was ...[more]