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Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

ABSTRACT: OBJECTIVE:To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). METHODS:We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off for KFLC and LFLC indexes. RESULTS:The cut-off for the KFLC index was 6.6 (95% confidence interval (CI)?=?5.2-138.1). The cut-off for the LFLC index was 6.9 (95% CI?=?4.5-22.2). For CIS/MS patients, sensitivity of the KFLC index (0.88; 95% CI?=?0.85-0.90) was higher than OCB (0.82; 95%CI?=?0.79-0.85; p?

SUBMITTER: Leurs CE 

PROVIDER: S-EPMC7350201 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study.

Leurs C E CE   Twaalfhoven Ham H   Lissenberg-Witte B I BI   van Pesch V V   Dujmovic I I   Drulovic J J   Castellazzi M M   Bellini T T   Pugliatti M M   Kuhle J J   Villar L M LM   Alvarez-Cermeño J C JC   Alvarez-Lafuente R R   Hegen H H   Deisenhammer F F   Walchhofer L M LM   Thouvenot E E   Comabella M M   Montalban X X   Vécsei L L   Rajda C C   Galimberti D D   Scarpini E E   Altintas A A   Rejdak K K   Frederiksen J L JL   Pihl-Jensen G G   Jensen Peh P   Khalil M M   Voortman M M MM   Fazekas F F   Saiz A A   La Puma D D   Vercammen M M   Vanopdenbosch L L   Uitdehaag Bmj B   Killestein J J   Bridel C C   Teunissen C C  

Multiple sclerosis (Houndmills, Basingstoke, England) 20190508 8

<h4>Objective</h4>To validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS).<h4>Methods</h4>We performed a multicenter study including 745 patients from 18 centers (219 controls and 526 clinically isolated syndrome (CIS)/MS patients) with a known oligoclonal IgG band (OCB) status. KFLC and LFLC were measured in paired cerebrospinal fluid (CSF) and serum samples. Gaussian mixture modeling was used to define a cut-off  ...[more]

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