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MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

ABSTRACT: Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas (n = 53), clear cell endometrial carcinomas (n = 6), endometrioid ovarian carcinomas (n = 19), and clear cell ovarian carcinomas (n = 11) were immunochemically stained for the protein MSX1 and evaluated using the immunoreactive score (IRS). A significant stronger expression of MSX1 was found in endometrioid endometrial carcinomas (p < 0.001), in grading 2 (moderate differentiation) (p = 0.001), and in tumor material of patients with no involvement of lymph nodes (p = 0.031). Correlations were found between MSX1 expression and the expression of ?-Catenin, p21, p53, and the steroid receptors ER?, ER?, PR?, and PR?. A significant (p = 0.023) better survival for patients with an MSX1 expression in more than 10% of the tumor cells was observed for endometrioid endometrial carcinomas (21.3 years median survival (MSX1-positive) versus 17.3 years (MSX1-negative)). Although there is evidence that MSX1 expression correlates with improved long-term survival, further studies are necessary to evaluate if MSX1 can be used as a prognostic marker.

SUBMITTER: Eppich S

PROVIDER: S-EPMC7350265 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

Eppich Simon S Kuhn Christina C Schmoeckel Elisa E Mayr Doris D Mahner Sven S Jeschke Udo U Gallwas Julia J Heidegger Helene Hildegard HH

International journal of molecular sciences 20200625 12

Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcinomas (n = 53), clear cell endometrial carcinomas (n = 6), endometrioid ovarian carcinomas (n = 19), and clear cell ovarian carcinomas (n = 11) were immunochemically stained for the protein MSX1 and evaluated using the immun ...[more]

PMID: 32630554

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Dataset Information

MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

Publications

MSX1-A Potential Marker for Uterus-Preserving Therapy of Endometrial Carcinomas.

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