Ontology highlight
ABSTRACT:
SUBMITTER: Lowery MA
PROVIDER: S-EPMC7351022 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Lowery Maeve A MA Kelsen David P DP Capanu Marinela M Smith Sloane C SC Lee Jonathan W JW Stadler Zsofia K ZK Moore Malcolm J MJ Kindler Hedy L HL Golan Talia T Segal Amiel A Maynard Hannah H Hollywood Ellen E Moynahan MaryEllen M Salo-Mullen Erin E EE Do Richard Kinh Gian RKG Chen Alice P AP Yu Kenneth H KH Tang Laura H LH O'Reilly Eileen M EM
European journal of cancer (Oxford, England : 1990) 20171208
<h4>Purpose</h4>BRCA-associated cancers have increased sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPis). This single arm, non-randomised, multicentre phase II trial evaluated the response rate of veliparib in patients with previously treated BRCA1/2- or PALB2-mutant pancreatic adenocarcinoma (PDAC).<h4>Methods</h4>Patients with stage III/IV PDAC and known germline BRCA1/2 or PALB2 mutation, 1-2 lines of treatment, Eastern Cooperative Oncology Group 0-2, were enrolled. Veliparib was ...[more]