Ontology highlight
ABSTRACT:
SUBMITTER: Maricque BB
PROVIDER: S-EPMC7351048 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature biotechnology 20181119
A gene's position in the genome can profoundly affect its expression because regional differences in chromatin modulate the activity of locally acting cis-regulatory sequences (CRSs). Here we study how CRSs and regional chromatin act in concert on a genome-wide scale. We present a massively parallel reporter gene assay that measures the activities of hundreds of different CRSs, each integrated at many specific genomic locations. Although genome location strongly affected CRS activity, the relati ...[more]