Brain metastases as preventive and therapeutic targets.
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ABSTRACT:
SUBMITTER: Steeg PS
PROVIDER: S-EPMC7351203 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Publications
Brain metastases as preventive and therapeutic targets.
Steeg Patricia S PS Camphausen Kevin A KA Smith Quentin R QR
Nature reviews. Cancer 20110407 5
The incidence of metastasis to the brain is apparently rising in cancer patients and threatens to limit the gains that have been made by new systemic treatments. The brain is considered a 'sanctuary site' as the blood-tumour barrier limits the ability of drugs to enter and kill tumour cells. Translational research examining metastasis to the brain needs to be multi-disciplinary, marrying advanced chemistry, blood-brain barrier pharmacokinetics, neurocognitive testing and radiation biology with m ...[more]
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