Ontology highlight
ABSTRACT:
SUBMITTER: Klug D
PROVIDER: S-EPMC7351488 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Klug Dennis D Goellner Sarah S Kehrer Jessica J Sattler Julia J Strauss Léanne L Singer Mirko M Lu Chafen C Springer Timothy A TA Frischknecht Friedrich F
eLife 20200710
Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomplexans such as TRAP in <i>Plasmodium</i> and MIC2 in <i>Toxoplasma</i>. Here we show that the I domain of TRAP is essential for sporozoite gliding motility, mosquito salivary gland invasion and mouse infection. Its replacement with the I domain from To ...[more]