Ontology highlight
ABSTRACT:
SUBMITTER: Pereira M
PROVIDER: S-EPMC7351491 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
eLife 20200619
Functional characterisation of cell-type-specific regulatory networks is key to establish a causal link between genetic variation and phenotype. The osteoclast offers a unique model for interrogating the contribution of co-regulated genes to in vivo phenotype as its multinucleation and resorption activities determine quantifiable skeletal traits. Here we took advantage of a <i>trans</i>-regulated gene network (MMnet, macrophage multinucleation network) which we found to be significantly enriched ...[more]