Dataset Information

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.

ABSTRACT:

Background

Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.

Methods

Objective [response bias assessed by the probabilistic reward task (PRT)] and subjective [Snaith-Hamilton Pleasure Scale (SHAPS)] measures of anhedonia, clinical variables and DNA samples were collected from 100 controls and 164 patients at McLean Hospital. An independent sample genotyped as part of the Psychiatric Genomics Consortium (PGC) was used to study the effect of putative GLP-1R polymorphisms linked to response bias in PRT on depression diagnosis.

Results

The C allele in rs1042044 was significantly associated with increased PRT response bias, when controlling for age, sex, case-control status and PRT discriminability. AA genotype of rs1042044 showed higher anhedonia phenotype based on SHAPS scores. However, analysis of PGC major depressive disorder data showed no association between rs1042044 and depression diagnosis.

Conclusion

Findings suggest a possible association of rs1042044 with anhedonia but no association with depression diagnosis.

SUBMITTER: Yapici-Eser H

PROVIDER: S-EPMC7351594 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.

Yapici-Eser Hale H Appadurai Vivek V Eren Candan Yasemin CY Yazici Dilek D Chen Chia-Yen CY Öngür Dost D Pizzagalli Diego A DA Werge Thomas T Hall Mei-Hua MH

Acta neuropsychiatrica 20200326 4

<h4>Background</h4>Glucagon-like peptide-1 receptors (GLP-1Rs) are widely expressed in the brain. Evidence suggests that they may play a role in reward responses and neuroprotection. However, the association of GLP-1R with anhedonia and depression diagnosis has not been studied. Here, we examined the association of GLP-1R polymorphisms with objective and subjective measures of anhedonia, as well as depression diagnosis.<h4>Methods</h4>Objective [response bias assessed by the probabilistic reward ...[more]

PMID: 32213216

Similar Datasets

Project description:ImportanceAnhedonia is a symptom of multiple psychiatric conditions in young adults that is associated with poorer mental health and psychosocial function and abnormal ventral striatum reward processing. Aberrant function of neural reward circuitry is well documented in anhedonia and other psychiatric disorders. Longitudinal studies to identify potential biomarkers associated with a reduction in anhedonia are necessary for the development of novel treatment targets.ObjectiveTo identify neural reward-processing factors associated with improved psychiatric symptoms and psychosocial function in a naturalistic, observational context.Design, setting, and participantsA longitudinal cohort follow-up study was conducted from March 1, 2014, to June 5, 2018, at the University of Pittsburgh Medical Center after baseline functional magnetic resonance imaging in 52 participants between the ages of 18 and 25 years who were experiencing psychological distress.Main outcomes and measuresParticipants were evaluated at baseline and 6 months. At baseline, participants underwent functional magnetic resonance imaging during a card-guessing monetary reward task. Participants completed measures of affective symptoms and psychosocial function at each visit. Neural activation during reward prediction error (RPE), a measure of reward learning, was determined using Statistical Parametric Mapping software. Neural reward regions with significant RPE activation were entered as regions associated with future symptoms in multiple linear regression models.ResultsA total of 52 young adults (42 women and 10 men; mean [SD] age, 21.4 [2.2] years) completed the study. Greater RPE activation in the left ventral striatum was associated with a decrease in anhedonia symptoms during a 6-month period (β = -6.152; 95% CI, -11.870 to -0.433; P = .04). The decrease in anhedonia between baseline and 6 months mediated the association between left ventral striatum activation to RPE and improvement in life satisfaction between baseline and 6 months (total [c path] association: β = 0.245; P = .01; direct [c' path] association: β = 0.133; P = .16; and indirect [ab path] association: 95% CI, 0.026-0.262). Results were not associated with psychotropic medication use.Conclusions and relevanceGreater left ventral striatum responsiveness to RPE may serve as a biomarker or potential target for novel treatments to improve the severity of anhedonia, overall mental health, and psychosocial function.

Dataset Information

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.

Background

Methods

Results

Conclusion

Publications

Association between GLP-1 receptor gene polymorphisms with reward learning, anhedonia and depression diagnosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets