Vitamin D status, cognitive decline and incident dementia: the Canadian Study of Health and Aging.

ABSTRACT:

Objective

Vitamin D could prevent cognitive decline because of its neuroprotective, anti-inflammatory and antioxidant properties. This study aimed to evaluate the associations of plasma 25-hydroxyvitamin D (25(OH)D) concentrations with global cognitive function and incident dementia, including Alzheimer's disease (AD).

Methods

The Canadian Study of Health and Aging is a 10-year cohort study of a representative sample of individuals aged 65 years or older. A total of 661 subjects initially without dementia with frozen blood samples and follow-up data were included. Global cognitive function was measured using the validated Modified Mini-Mental State (3MS) examination. A consensus diagnosis of all-cause dementia and AD was made between the physician and the neuropsychologist a

SUBMITTER: Duchaine CS 

PROVIDER: S-EPMC7351937 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature