Ontology highlight
ABSTRACT:
SUBMITTER: Marin JJG
PROVIDER: S-EPMC7352164 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cancers 20200623 6
The poor outcome of patients with non-surgically removable advanced hepatocellular carcinoma (HCC), the most frequent type of primary liver cancer, is mainly due to the high refractoriness of this aggressive tumor to classical chemotherapy. Novel pharmacological approaches based on the use of inhibitors of tyrosine kinases (TKIs), mainly sorafenib and regorafenib, have provided only a modest prolongation of the overall survival in these HCC patients. The present review is an update of the availa ...[more]