Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions.
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SUBMITTER: Catarata MJ
PROVIDER: S-EPMC7352181 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
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Renin-Angiotensin System in Lung Tumor and Microenvironment Interactions.
Catarata Maria Joana MJ Ribeiro Ricardo R Oliveira Maria José MJ Robalo Cordeiro Carlos C Medeiros Rui R
Cancers 20200603 6
The mechanistic involvement of the renin-angiotensin system (RAS) reaches beyond cardiovascular physiopathology. Recent knowledge pinpoints a pleiotropic role for this system, particularly in the lung, and mainly through locally regulated alternative molecules and secondary pathways. Angiotensin peptides play a role in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. This manuscript reviews the literature supportin ...[more]
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