Ontology highlight
ABSTRACT:
SUBMITTER: Santiago-Sanchez GS
PROVIDER: S-EPMC7352275 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Santiago-Sánchez Ginette S GS Pita-Grisanti Valentina V Quiñones-Díaz Blanca B Gumpper Kristyn K Cruz-Monserrate Zobeida Z Vivas-Mejía Pablo E PE
International journal of molecular sciences 20200619 12
Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes, modulating immune responses, maintaining iron homeostasis, and promoting epithelial cell differentiation. Although LNC2 is expressed at low levels in most human tissues, it is abundant in aggressive subtypes of cancer, including breast, pancreas, thyroid, ovarian, colon, and bile duct cancers. High levels of LCN2 have been associated with increase ...[more]