Ontology highlight
ABSTRACT:
SUBMITTER: Choi HS
PROVIDER: S-EPMC7352364 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Choi Hae-Seul HS Pei Chang-Zhu CZ Park Jun-Hyeok JH Kim Soo-Yeon SY Song Seung-Yeon SY Shin Gyeong-Jin GJ Baek Kwang-Hyun KH
Cancers 20200612 6
The ubiquitin-proteasome system (UPS) is responsible for proteasomal degradation, regulating the half-life of the protein. Deubiquitinating enzymes (DUBs) are components of the UPS and inhibit degradation by removing ubiquitins from protein substrates. Herpesvirus-associated ubiquitin-specific protease (HAUSP) is one such deubiquitinating enzyme and has been closely associated with tumor development. In a previous study, we isolated putative HAUSP binding substrates by two-dimensional electropho ...[more]