Inhibition of ATM Increases the Radiosensitivity of Uveal Melanoma Cells to Photons and Protons.

ABSTRACT: Treatment of uveal melanoma (UM) is generally successful, with local primary tumour control being at 90%-95%. Localized radiotherapy in the form of plaque brachytherapy or proton beam radiotherapy is the most common treatment modality in the UK. However, the basic mechanisms of radiation response, DNA repair and tissue reactions in UM have not been well documented previously. We have investigated the comparative radiosensitivity of four UM cell lines in response to exogenous radiation sources (both X-rays and protons), and correlated this with DNA repair protein expression and repair efficiency. We observed a broad range of radiosensitivity of different UM cell lines to X-rays and protons, with increased radioresistance correlating with elevated protein expression of ataxia telangiectasia

SUBMITTER: Hussain RN 

PROVIDER: S-EPMC7352388 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature