Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity.
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ABSTRACT:
SUBMITTER: Hajeri PB
PROVIDER: S-EPMC7352392 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Publications
Oncolytic Adenoviruses: Strategies for Improved Targeting and Specificity.
Hajeri Praveensingh B PB Sharma Nikita S NS Yamamoto Masato M
Cancers 20200609 6
Cancer is a major health problem. Most of the treatments exhibit systemic toxicity, as they are not targeted or specific to cancerous cells and tumors. Adenoviruses are very promising gene delivery vectors and have immense potential to deliver targeted therapy. Here, we review a wide range of strategies that have been tried, tested, and demonstrated to enhance the specificity of oncolytic viruses towards specific cancer cells. A combination of these strategies and other conventional therapies ma ...[more]
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