Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma.
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ABSTRACT:
SUBMITTER: Sangineto M
PROVIDER: S-EPMC7352397 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
Lipid Metabolism in Development and Progression of Hepatocellular Carcinoma.
Sangineto Moris M Villani Rosanna R Cavallone Francesco F Romano Antonino A Loizzi Domenico D Serviddio Gaetano G
Cancers 20200531 6
<b>:</b> Metabolic reprogramming is critically involved in the development and progression of cancer. In particular, lipid metabolism has been investigated as a source of energy, micro-environmental adaptation, and cell signalling in neoplastic cells. However, the specific role of lipid metabolism dysregulation in hepatocellular carcinoma (HCC) has not been widely described yet. Alterations in fatty acid synthesis, β-oxidation, and cellular lipidic composition contribute to initiation and progre ...[more]
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