Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned so Far.

ABSTRACT: Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor kinase class that controls multiple signaling pathways in animal cells. SFKs activation is necessary for the mitogenic signal from many growth factors, but also for the acquisition of migratory and invasive phenotype. Indeed, oncogenic activation of SFKs has been demonstrated to play an important role in solid cancers; promoting tumor growth and formation of distant metastases. Several drugs targeting SFKs have been developed and tested in preclinical models and many of them have successfully reached clinical use in hematologic cancers. Although in solid tumors SFKs inhibitors have consistently confirmed their ability in blocking cancer cell progression in several experimental models; their utilization

SUBMITTER: Martellucci S 

PROVIDER: S-EPMC7352436 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature