Ontology highlight
ABSTRACT:
SUBMITTER: Martellucci S
PROVIDER: S-EPMC7352436 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Martellucci Stefano S Clementi Letizia L Sabetta Samantha S Mattei Vincenzo V Botta Lorenzo L Angelucci Adriano A
Cancers 20200602 6
Src is the prototypal member of Src Family tyrosine Kinases (SFKs), a large non-receptor kinase class that controls multiple signaling pathways in animal cells. SFKs activation is necessary for the mitogenic signal from many growth factors, but also for the acquisition of migratory and invasive phenotype. Indeed, oncogenic activation of SFKs has been demonstrated to play an important role in solid cancers; promoting tumor growth and formation of distant metastases. Several drugs targeting SFKs h ...[more]