Ontology highlight
ABSTRACT:
SUBMITTER: Kierulf-Vieira KS
PROVIDER: S-EPMC7352564 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kierulf-Vieira Kirsten Strømme KS Sandberg Cecilie Jonsgar CJ Waaler Jo J Lund Kaja K Skaga Erlend E Saberniak Birthe Mikkelsen BM Panagopoulos Ioannis I Brandal Petter P Krauss Stefan S Langmoen Iver Arne IA Vik-Mo Einar Osland EO
Cancers 20200619 6
Evidence suggests that the growth and therapeutic resistance of glioblastoma (GBM) may be enabled by a population of glioma stem cells (GSCs) that are regulated by typical stem cell pathways, including the WNT/β-catenin signaling pathway. We wanted to explore the effect of treating GSCs with a small-molecule inhibitor of tankyrase, G007-LK, which has been shown to be a potent modulator of the WNT/β-catenin and Hippo pathways in colon cancer. Four primary GSC cultures and two primary adult neural ...[more]