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Human Milk Fatty Acid Composition of Allergic and Non-Allergic Mothers: The Ulm SPATZ Health Study.


ABSTRACT: The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between mothers with or without allergy. Observed differences in our results between transformed and untransformed fatty acid data call for re-evaluation of previous, as well as future, studies using statistical methods appropriate for compositionality of fatty acid data.

SUBMITTER: Siziba LP 

PROVIDER: S-EPMC7352579 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Human Milk Fatty Acid Composition of Allergic and Non-Allergic Mothers: The Ulm SPATZ Health Study.

Siziba Linda P LP   Lorenz Leonie L   Stahl Bernd B   Mank Marko M   Marosvölgyi Tamas T   Decsi Tamas T   Rothenbacher Dietrich D   Genuneit Jon J  

Nutrients 20200610 6


The aim of this study was to determine the differences in human milk fatty acid composition in relation to maternal allergy within a large birth cohort study using statistical methods accounting for the correlations that exist in compositional data. We observed marginal differences in human milk fatty acid composition of allergic and non-allergic mothers. However, our results do not support the hypothesis that human milk fatty acid composition is influenced by allergy or that it differs between  ...[more]

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