Ontology highlight
ABSTRACT:
SUBMITTER: Santana-Viera L
PROVIDER: S-EPMC7352655 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cancers 20200526 6
Tumor mass consists of a complex ensemble of malignant cancer cells and a wide variety of resident and infiltrating cells, secreted factors, and extracellular matrix proteins that are referred as tumor microenvironment (TME). Cancer associated fibroblasts (CAFs) are key TME components that support tumor growth, generating a physical barrier against drugs and immune infiltration, and contributing to regulate malignant progression. Thus, it is largely accepted that therapeutic approaches aimed at ...[more]