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Structure, Function, and Regulation of the SRMS Tyrosine Kinase.

ABSTRACT: Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a tyrosine kinase that was discovered in 1994. It is a member of a family of nonreceptor tyrosine kinases that also includes Brk (PTK6) and Frk. Compared with other tyrosine kinases, there is relatively little information about the structure, function, and regulation of SRMS. In this review, we summarize the current state of knowledge regarding SRMS, including recent results aimed at identifying downstream signaling partners. We also present a structural model for the enzyme and discuss the potential involvement of SRMS in cancer cell signaling.

SUBMITTER: McClendon CJ

PROVIDER: S-EPMC7352994 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Structure, Function, and Regulation of the SRMS Tyrosine Kinase.

McClendon Chakia J CJ Miller W Todd WT

International journal of molecular sciences 20200614 12

Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristoylation sites (SRMS) is a tyrosine kinase that was discovered in 1994. It is a member of a family of nonreceptor tyrosine kinases that also includes Brk (PTK6) and Frk. Compared with other tyrosine kinases, there is relatively little information about the structure, function, and regulation of SRMS. In this review, we summarize the current state of knowledge regarding SRMS, including recent results aimed at identifyi ...[more]

PMID: 32545875

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