Ontology highlight
ABSTRACT:
SUBMITTER: Tamashunas AC
PROVIDER: S-EPMC7353136 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Tamashunas Andrew C AC Tocco Vincent J VJ Matthews James J Zhang Qiao Q Atanasova Kalina R KR Paschall Lauren L Pathak Shreya S Ratnayake Ranjala R Stephens Andrew D AD Luesch Hendrik H Licht Jonathan D JD Lele Tanmay P TP
Molecular biology of the cell 20200422 13
Irregular nuclear shapes characterized by blebs, lobules, micronuclei, or invaginations are hallmarks of many cancers and human pathologies. Despite the correlation between abnormal nuclear shape and human pathologies, the mechanism by which the cancer nucleus becomes misshapen is not fully understood. Motivated by recent evidence that modifying chromatin condensation can change nuclear morphology, we conducted a high-throughput RNAi screen to identify epigenetic regulators that are required to ...[more]