Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7354446 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Zhang Yujiao Y Gao Fei F Li Liwei L Zhao Kuan K Jiang Shan S Jiang Yifeng Y Yu Lingxue L Zhou Yanjun Y Liu Changlong C Tong Guangzhi G
Viruses 20200617 6
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important pathogens in the swine industry worldwide. Our previous study had indicated that proprotein convertase subtilisin/kexin type 9 (PCSK9) was a responsive gene in porcine alveolar macrophages (PAMs) upon PRRSV infection. However, whether PCSK9 impacts the PRRSV replication and how the PRRSV modulates host PCSK9 remains elusive. Here, we demonstrated that PCSK9 protein suppressed the replication of both type-1 a ...[more]