Ontology highlight
ABSTRACT:
SUBMITTER: Zhang P
PROVIDER: S-EPMC7355335 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Pengfei P Yu Linyang L Dong Jianguo J Liu Yanling Y Zhang Leyi L Liang Pengshuai P Wang Lei L Chen Bin B Huang Li L Song Changxu C
Veterinary microbiology 20200713
Porcine epidemic diarrhea virus (PEDV) belongs to the Alphacoronavirus genus in the Coronaviridae family. Similar to other coronaviruses, PEDV encodes two papain-like proteases. Papain-like protease (PLP)2 has been proposed to play a key role in antagonizing host innate immunity. However, the function of PLP1 remains unclear. In this study, we found that overexpression of PLP1 significantly promoted PEDV replication and inhibited production of interferon-β. Immunoprecipitation and mass spectrome ...[more]