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Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-Staphylococcus aureus Agents.

ABSTRACT: In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant Staphylococcus aureus (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of the most menacing pathogens of humans and this bacterium is bypassing HIV in terms of fatality rate.

SUBMITTER: Alnufaie R

PROVIDER: S-EPMC7356691 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Synthesis and Antimicrobial Studies of Coumarin-Substituted Pyrazole Derivatives as Potent Anti-<i>Staphylococcus aureus</i> Agents.

Alnufaie Rawan R Raj Kc Hansa H Alsup Nickolas N Whitt Jedidiah J Andrew Chambers Steven S Gilmore David D Alam Mohammad A MA

Molecules (Basel, Switzerland) 20200615 12

In this paper, synthesis and antimicrobial studies of 31 novel coumarin-substituted pyrazole derivatives are reported. Some of these compounds have shown potent activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) with minimum inhibitory concentration (MIC) as low as 3.125 µg/mL. These molecules are equally potent at inhibiting the development of MRSA biofilm and the destruction of preformed biofilm. These results are very significant as MRSA strains have emerged as one of ...[more]

PMID: 32549248

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