Unknown

Dataset Information

0

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases.

ABSTRACT: NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseases.

SUBMITTER: Cores A 

PROVIDER: S-EPMC7356958 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

NRF2 Regulation Processes as a Source of Potential Drug Targets against Neurodegenerative Diseases.

Cores Ángel Á   Piquero Marta M   Villacampa Mercedes M   León Rafael R   Menéndez J Carlos JC  

Biomolecules 20200614 6

NRF2 acts by controlling gene expression, being the master regulator of the Phase II antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity is regulated at several levels, including protein degradation by the proteasome, transcription, and post-transcription. The purpose of this review is to offer a concise and critical overview of the main mechanisms of NRF2 regulation and their actual or potential use as targets for the treatment of neurodegenerative diseas  ...[more]

Similar Datasets

Unknown A Potential Alternative against Neurodegenerative Diseases: Phytodrugs.
| S-EPMC4736801 | biostudies-other
Unknown In Silico Studies in Drug Research Against Neurodegenerative Diseases.
| S-EPMC6080098 | biostudies-literature
Unknown Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases.
| S-EPMC7393579 | biostudies-literature
Unknown Regulator of G-protein Signaling (RGS)1 and RGS10 Proteins as Potential Drug Targets for Neuroinflammatory and Neurodegenerative Diseases.
| S-EPMC5256602 | biostudies-literature
Unknown Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.
| S-EPMC3466564 | biostudies-literature
Unknown Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases.
| S-EPMC7186402 | biostudies-literature
Unknown Nrf2--a therapeutic target for the treatment of neurodegenerative diseases.
| S-EPMC4809057 | biostudies-literature
Unknown Does Ceruloplasmin Defend Against Neurodegenerative Diseases?
| S-EPMC6712297 | biostudies-literature
Unknown Eckol as a Potential Therapeutic against Neurodegenerative Diseases Targeting Dopamine D?/D? Receptors.
| S-EPMC6409773 | biostudies-literature
Proteomics Tau interactome mapping reveals dynamic processes associated with neurodegenerative diseases
2022-01-11 | PXD026306 | Pride