Ontology highlight
ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC7357111 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Wang Miao M You Sung-Kyun SK Lee Hong-Ki HK Han Min-Gu MG Lee Hyeon-Min HM Pham Thi Mai Anh TMA Na Young-Guk YG Cho Cheong-Weon CW
Pharmaceutics 20200612 6
Docetaxel (DTX) has clinical efficacy in the treatment of breast cancer, but it is difficult to develop a product for oral administration, due to low solubility and permeability. This study focused on preparing a self-microemulsifying drug delivery system (SME) loaded with DTX-phospholipid complex (DTX@PLC), to improve the dissolution and gastrointestinal (GI) permeability of DTX. A dual technique combining the phospholipid complexation and SME formulation described as improving upon the disadva ...[more]