Ontology highlight
ABSTRACT:
SUBMITTER: Micali N
PROVIDER: S-EPMC7357345 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cell reports 20200501 5
Better understanding of the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here, we use RNA sequencing, cell imaging, and lineage tracing of mouse and human in vitro NSCs and monkey brain sections to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate the acute transition from proliferative NSCs to committed glutamatergic ...[more]