Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC7357548 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Liu Shuying S Li Shunqiang S Wang Bailiang B Liu Wenbin W Gagea Mihai M Chen Huiqin H Sohn Joohyuk J Parinyanitikul Napa N Primeau Tina T Do Kim-Anh KA Vande Woude George F GF Mendelsohn John J Ueno Naoto T NT Mills Gordon B GB Tripathy Debu D Gonzalez-Angulo Ana M AM
Molecular cancer therapeutics 20181205 2
There is compelling evidence that oncogenic <i>MET</i> and <i>PIK3CA</i> signaling pathways contribute to breast cancer. However, the activity of pharmacologic targeting of either pathway is modest. Mechanisms of resistance to these monotherapies have not been clarified. Currently, commonly used mouse models are inadequate for studying the HGF-MET axis because mouse HGF does not bind human MET. We established human HGF-MET paired mouse models. In this study, we evaluated the cooperative effects ...[more]