Ontology highlight
ABSTRACT:
SUBMITTER: Bader G
PROVIDER: S-EPMC7358010 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Bader Gaétan G Enkler Ludovic L Araiso Yuhei Y Hemmerle Marine M Binko Krystyna K Baranowska Emilia E De Craene Johan-Owen JO Ruer-Laventie Julie J Pieters Jean J Tribouillard-Tanvier Déborah D Senger Bruno B di Rago Jean-Paul JP Friant Sylvie S Kucharczyk Roza R Becker Hubert Dominique HD
eLife 20200713
A single nuclear gene can be translated into a dual localized protein that distributes between the cytosol and mitochondria. Accumulating evidences show that mitoproteomes contain lots of these dual localized proteins termed echoforms. Unraveling the existence of mitochondrial echoforms using current GFP (Green Fluorescent Protein) fusion microscopy approaches is extremely difficult because the GFP signal of the cytosolic echoform will almost inevitably mask that of the mitochondrial echoform. W ...[more]