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On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19.

ABSTRACT: The present review summarizes up-to-date evidence addressing the frequently discussed clinical controversies regarding the use of immune checkpoint inhibitors (ICIs) in cancer patients with viral infections, including AIDS, hepatitis B and C, progressive multifocal leukoencephalopathy, influenza, and COVID-19. In detail, we provide available information on (1) safety regarding the risk of new infections, (2) effects on the outcome of pre-existing infections, (3) whether immunosuppressive drugs used to treat ICI-related adverse events affect the risk of infection or virulence of pre-existing infections, (4) whether the use of vaccines in ICI-treated patients is considered safe, and (5) whether there are beneficial effects of ICIs that even qualify them as a therapeutic approach for these viral infections.

SUBMITTER: Gambichler T

PROVIDER: S-EPMC7358098 | biostudies-literature |

REPOSITORIES: biostudies-literature

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NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators?

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Project description: Not available

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