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DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address this issue, the best way would be to find biomarkers and new therapeutic targets for COPD. DNA methylation (DNAm) may be a potential biomarker for disease prevention, diagnosis, and prognosis, and its reversibility further makes it a potential drug design target in COPD. In this review, we aimed to explore the role of DNAm as biomarkers and disease mediators in different tissue samples from patients with COPD.

SUBMITTER: He LX

PROVIDER: S-EPMC7358425 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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DNA Methylation: A Potential Biomarker of Chronic Obstructive Pulmonary Disease.

He Lin-Xi LX Tang Zhao-Hui ZH Huang Qing-Song QS Li Wei-Hong WH

Frontiers in cell and developmental biology 20200707

Chronic obstructive pulmonary disease (COPD) is a serious public health concern worldwide. By 2040, 4.41 million people are estimated to expire annually due to COPD. However, till date, it has remained difficult to alter the activity or progress of the disease through treatment. In order to address this issue, the best way would be to find biomarkers and new therapeutic targets for COPD. DNA methylation (DNAm) may be a potential biomarker for disease prevention, diagnosis, and prognosis, and its ...[more]

PMID: 32733890

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