Unknown

Dataset Information

0

Impaired phonemic discrimination in logopenic variant primary progressive aphasia.

ABSTRACT: Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer's disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-based morphometry correlated phonemic discrimination score with grey matter in left angular gyrus. Our findings suggest that impaired phonemic discrimination may help differentiate lvPPA from other PPA subtypes, with important diagnostic and management implications.

SUBMITTER: Johnson JCS 

PROVIDER: S-EPMC7359108 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Logopenic variant primary progressive aphasia (lvPPA) is the least well defined of the major primary progressive aphasia (PPA) syndromes. We assessed phoneme discrimination in patients with PPA (semantic, nonfluent/agrammatic, and logopenic variants) and typical Alzheimer's disease, relative to healthy age-matched participants. The lvPPA group performed significantly worse than all other groups apart from tAD, after adjusting for auditory verbal working memory. In the combined PPA cohort, voxel-  ...[more]

Similar Datasets

Unknown The logopenic variant of primary progressive aphasia.
| S-EPMC3201824 | biostudies-literature
Unknown The logopenic/phonological variant of primary progressive aphasia.
| S-EPMC2676989 | biostudies-literature
Unknown Case Report: Semantic Variant Primary Progressive Aphasia With Impaired Verbal Word Discrimination.
| S-EPMC9243420 | biostudies-literature
Unknown Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.
| S-EPMC7364264 | biostudies-literature
Unknown Cortical Tracking of the Speech Envelope in Logopenic Variant Primary Progressive Aphasia.
| S-EPMC7815818 | biostudies-literature
Unknown A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia.
| S-EPMC7175926 | biostudies-literature
Unknown Patterns of longitudinal brain atrophy in the logopenic variant of primary progressive aphasia.
| S-EPMC3880853 | biostudies-literature
Unknown Clinical and neuroimaging biomarkers of amyloid-negative logopenic primary progressive aphasia.
| S-EPMC4380294 | biostudies-literature
Unknown Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia.
| S-EPMC5567322 | biostudies-literature
Unknown Taxonomic Interference Associated with Phonemic Paraphasias in Agrammatic Primary Progressive Aphasia.
| S-EPMC7174997 | biostudies-literature