Dataset Information

Genetics of structural and functional brain changes in autism spectrum disorder.

ABSTRACT: Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific single-nucleotide polymorphisms, and the study of genetic mechanisms and noninvasive imaging has opened various approaches that can help diagnose ASD at the nascent level. Identifying risk genes related to structural and functional changes in the brain of ASD patients provide a better understanding of the disease's neuropsychiatry and can help identify targets for therapeutic intervention that could be useful for the clinical management of ASD patients.

SUBMITTER: Hashem S

PROVIDER: S-EPMC7359361 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Genetics of structural and functional brain changes in autism spectrum disorder.

Hashem Sheema S Nisar Sabah S Bhat Ajaz A AA Bhat Ajaz A AA Yadav Santosh Kumar SK Azeem Muhammad Waqar MW Bagga Puneet P Fakhro Khalid K Reddy Ravinder R Frenneaux Michael P MP Haris Mohammad M

Translational psychiatry 20200713 1

Autism spectrum disorder (ASD) is a neurological and developmental disorder characterized by social impairment and restricted interactive and communicative behaviors. It may occur as an isolated disorder or in the context of other neurological, psychiatric, developmental, and genetic disorders. Due to rapid developments in genomics and imaging technologies, imaging genetics studies of ASD have evolved in the last few years. Increased risk for ASD diagnosis is found to be related to many specific ...[more]

PMID: 32661244

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Project description:This study attempted to answer the question, "Can filtering the functional data through the frequency bands of the structural graph provide data with valuable features which are not valuable in unfiltered data"?. The valuable features discriminate between autism spectrum disorder (ASD) and typically control (TC) groups. The resting-state fMRI data was passed through the structural graph's low, middle, and high-frequency band (LFB, MFB, and HFB) filters to answer the posed question. The structural graph was computed using the diffusion tensor imaging data. Then, the global metrics of functional graphs and metrics of functional triadic interactions were computed for filtered and unfiltered rfMRI data. Compared to TCs, ASDs had significantly higher clustering coefficients in the MFB, higher efficiencies and strengths in the MFB and HFB, and lower small-world propensity in the HFB. These results show over-connectivity, more global integration, and decreased local specialization in ASDs compared to TCs. Triadic analysis showed that the numbers of unbalanced triads were significantly lower for ASDs in the MFB. This finding may indicate the reason for restricted and repetitive behavior in ASDs. Also, in the MFB and HFB, the numbers of balanced triads and the energies of triadic interactions were significantly higher and lower for ASDs, respectively. These findings may reflect the disruption of the optimum balance between functional integration and specialization. There was no significant difference between ASDs and TCs when using the unfiltered data. All of these results demonstrated that significant differences between ASDs and TCs existed in the MFB and HFB of the structural graph when analyzing the global metrics of the functional graph and triadic interaction metrics. Also, these results demonstrated that frequency bands of the structural graph could offer significant findings which were not found in the unfiltered data. In conclusion, the results demonstrated the promising perspective of using structural graph frequency bands for attaining discriminative features and new knowledge, especially in the case of ASD.

Dataset Information

Genetics of structural and functional brain changes in autism spectrum disorder.

Publications

Genetics of structural and functional brain changes in autism spectrum disorder.

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