Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein.

ABSTRACT: Background:The biological pathways through which vitamin D is involved in the regulation of systemic inflammation remain largely unknown. Objective:The objective of this study was to evaluate the role of vitamin D status on the relationship between lipid profile and high-sensitivity C-reactive protein (hs-CRP) in pregnant women. Design:Serum 25-hydroxyvitamin D (25(OH)D), hs-CRP, and indicators of lipid profiles (total cholesterol, TC; triglyceride, TG; high-density lipoprotein cholesterol, HDL-C; low-density lipoprotein cholesterol, LDL-C), were measured in 2479 pregnant women during the second trimester. Potential confounding including maternal sociodemographic characteristics, perinatal health status, diet, and lifestyle was prospectively collected. Multiple regression models and cubic models were used to evaluate the associations. Results:There was a significant non-linear relationship between lipid profile (TC, TG, HDL-C, LDL-C) and hs-CRP (P?

SUBMITTER: Jin D 

PROVIDER: S-EPMC7359462 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature