Unknown

Dataset Information

0

Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study.


ABSTRACT: There are plausible mechanisms by which angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of COVID-19 infection or affect disease severity. To examine the association between these medications and COVID-19 infection or hospitalization, we conducted a retrospective cohort study within a US integrated healthcare system. Among people aged ?18 years enrolled in the health plan for at least 4 months as of 2/29/2020, current ACEI and ARB use was identified from pharmacy data, and the estimated daily dose was calculated and standardized across medications. COVID-19 infections were identified through 6/14/2020 from laboratory and hospitalization data. We used logistic regression to estimate adjusted odds ratios (ORs) and 95% confidence intervals. Among 322,044 individuals, 720 developed COVID-19 infection. Among people using ACEI/ARBs, 183/56,105 developed COVID-19 (3.3 per 1000 individuals) compared with 537/265,939 without ACEI/ARB use (2.0 per 1000), yielding an adjusted OR of 0.94 (95% CI 0.75-1.16). For use of < 1 defined daily dose vs. nonuse, the adjusted OR for infection was 0.89 (95% CI 0.62-1.26); for 1 to < 2 defined daily doses, 0.97 (95% CI 0.71-1.31); and for ?2 defined daily doses, 0.94 (95% CI 0.72-1.23). The OR was similar for ACEIs and ARBs and in subgroups by age and sex. 29% of people with COVID-19 infection were hospitalized; the adjusted OR for hospitalization in relation to ACEI/ARB use was 0.92 (95% CI 0.54-1.57), and there was no association with dose. These findings support current recommendations that individuals on these medications continue their use.

SUBMITTER: Dublin S 

PROVIDER: S-EPMC7359535 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

altmetric image

Publications

Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study.

Dublin Sascha S   Walker Rod R   Floyd James S JS   Shortreed Susan M SM   Fuller Sharon S   Albertson-Junkans Ladia L   Harrington Laura B LB   Greenwood-Hickman Mikael Anne MA   Green Beverly B BB   Psaty Bruce M BM  

medRxiv : the preprint server for health sciences 20200707


There are plausible mechanisms by which angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of COVID-19 infection or affect disease severity. To examine the association between these medications and COVID-19 infection or hospitalization, we conducted a retrospective cohort study within a US integrated healthcare system. Among people aged ≥18 years enrolled in the health plan for at least 4 months as of 2/29/2020, current ACEI and ARB us  ...[more]

Similar Datasets

| S-EPMC7665332 | biostudies-literature
| S-EPMC9206216 | biostudies-literature
| S-EPMC7172808 | biostudies-literature
| S-EPMC7224604 | biostudies-literature
| S-EPMC7206932 | biostudies-literature
| S-EPMC7121452 | biostudies-literature
| S-EPMC8475700 | biostudies-literature
| S-EPMC8237039 | biostudies-literature
| S-EPMC9999244 | biostudies-literature
| S-EPMC7951918 | biostudies-literature