Antimicrobial Therapy in Septic Shock Is Conservative During Resuscitation and Maintenance Phases.

ABSTRACT: Background: Maximal dosing of early antimicrobials with high loading and maintenance doses may optimize pharmacokinetic parameters to achieve and maintain therapeutic concentrations at the site of infection in septic shock. Little is known about the current practice of early antimicrobial dosing in septic shock. Objective: To characterize early antimicrobial dosing in patients in the resuscitation phase of septic shock. Methods: This retrospective cohort study included patients admitted to the medical intensive care unit (ICU) with septic shock. The primary outcome was the percentage of early antibiotic orders that were maximal or conservative during the resuscitation (0 to 48 hours) phase based on predefined dosing criteria. The secondary outcomes were the correlation

SUBMITTER: Hsu G 

PROVIDER: S-EPMC7359664 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature