Ontology highlight
ABSTRACT:
SUBMITTER: Nyitrai H
PROVIDER: S-EPMC7360120 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nyitrai Hajnalka H Wang Shan Shan H SSH Kaeser Pascal S PS
Cell reports 20200601 10
Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secretion, associates with mobile axonal cargo and localizes to nerve terminals. ELKS1 is a stationary presynaptic protein with Golgin homology that binds to Rab6. Knockout and rescue e ...[more]