Ontology highlight
ABSTRACT:
SUBMITTER: Folkesson E
PROVIDER: S-EPMC7360566 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Folkesson Evelina E Niederdorfer Barbara B Nakstad Vu To VT Thommesen Liv L Klinkenberg Geir G Lægreid Astrid A Flobak Åsmund Å
Scientific reports 20200714 1
Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on identification of synergistic drug combinations in vitro, we studied response to 21 clinically relevant drug combinations in standard planar (2D) layouts and physiologically more relevant spheroid (3D) cultures of HCT-116, HT-29 and SW-620 cells. By assessing changes in viability, c ...[more]