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Metabolic-associated fatty liver disease is associated with severity of COVID-19.

ABSTRACT: The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity has not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients without MAFLD. Our results demonstrate that in patients aged less than 60 years with COVID-19, MAFLD is associated with an approximately fourfold increase (adjusted odds ratio 4.07, 95% confidence interval 1.20-13.79, P = .02) in the probability for severe disease, after adjusting for confounders. Healthcare professionals caring for patients with COVID-19 need to be aware that there is a positive association between MAFLD and severe illness with COVID-19.

SUBMITTER: Zhou YJ 

PROVIDER: S-EPMC7361853 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Metabolic-associated fatty liver disease is associated with severity of COVID-19.

Zhou Yu-Jie YJ   Zheng Kenneth I KI   Wang Xiao-Bo XB   Sun Qing-Feng QF   Pan Ke-Hua KH   Wang Ting-Yao TY   Ma Hong-Lei HL   Chen Yong-Ping YP   George Jacob J   Zheng Ming-Hua MH  

Liver international : official journal of the International Association for the Study of the Liver 20200705 9

The Corona Virus Disease 2019 (COVID-19) pandemic has attracted increasing worldwide attention. While metabolic-associated fatty liver disease (MAFLD) affects a quarter of world population, its impact on COVID-19 severity has not been characterized. We identified 55 MAFLD patients with COVID-19, who were 1:1 matched by age, sex and obesity status to non-aged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients without MAFLD. Our results demonstrate that in patients aged  ...[more]

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