Ontology highlight
ABSTRACT:
SUBMITTER: Li Z
PROVIDER: S-EPMC7362189 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Li Ziduo Z Abadir Edward E Lee Kenneth K Lee Kenneth K Clarke Candice C Bryant Christian E CE Cooper Wendy W Pietersz Geoffrey G Favaloro James J Silveira Pablo A PA Nj Hart Derek D Ju Xinsheng X Clark Georgina J GJ
Clinical & translational immunology 20200715 7
<h4>Objectives</h4>Effective antibody-drug conjugates (ADCs) provide potent targeted cancer therapies. CD83 is expressed on activated immune cells including B cells and is a therapeutic target for Hodgkin lymphoma. Our objective was to determine CD83 expression on non-Hodgkin lymphoma (NHL) and its therapeutic potential to treat mantle cell lymphoma (MCL) which is currently an incurable NHL.<h4>Methods</h4>We analysed CD83 expression on MCL cell lines and the lymph node/bone marrow biopsies of M ...[more]