A unique immune signature of serum cytokine and chemokine dynamics in patients with Zika virus infection from a tropical region in Southern Mexico.
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ABSTRACT:
SUBMITTER: Zuniga J
PROVIDER: S-EPMC7362833 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
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A unique immune signature of serum cytokine and chemokine dynamics in patients with Zika virus infection from a tropical region in Southern Mexico.
Zuñiga Joaquín J Choreño-Parra José Alberto JA Jiménez-Alvarez Luis L Cruz-Lagunas Alfredo A Márquez-García José Eduardo JE Ramírez-Martínez Gustavo G Goodina Aminadab A Hernández-Montiel Erika E Fernández-López Luis Alejandro LA Cabrera-Cornejo María Fernanda MF Cabello Carlos C Castillejos Manuel M Hernández Andrés A Regino-Zamarripa Nora E NE Mendoza-Milla Criselda C Vivanco-Cid Héctor H Escobar-Gutierrez Alejandro A Fonseca-Coronado Salvador S Belaunzarán-Zamudio Pablo F PF Pérez-Patrigeon Santiago S Guerrero Lourdes L Regalado Justino J Nájera-Cancino Gabriel G Caballero-Sosa Sandra S Rincón-León Héctor H Smolskis Mary M Mateja Allyson A Hunsberger Sally S Beigel John H JH Ruiz-Palacios Guillermo G
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20200217
<h4>Objectives</h4>To describe the kinetics of circulating cytokines and chemokines in humans with ZIKAV infection.<h4>Methods</h4>Serum levels of different immune mediators in patients with ZIKAV infection were measured at distinct stages of the disease, as well as in culture supernatants from human monocytes infected with a clinical ZIKAV isolate. We also looked for clinical features associated with specific immune signatures among symptomatic patients.<h4>Results</h4>We evaluated 23 ZIKAV-inf ...[more]
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