Ontology highlight
ABSTRACT:
SUBMITTER: Cai LX
PROVIDER: S-EPMC7363446 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Cai Lili X LX Pizano Katherine K Gundersen Gregory W GW Hayes Cameron L CL Fleming Weston T WT Holt Sebastian S Cox Julia M JM Witten Ilana B IB
eLife 20200610
Dopamine (DA) neurons are to encode reward prediction error (RPE), in addition to other signals, such as salience. While RPE is known to support learning, the role of salience in learning remains less clear. To address this, we recorded and manipulated VTA DA neurons in mice during fear extinction. We applied deep learning to classify mouse freezing behavior, eliminating the need for human scoring. Our fiber photometry recordings showed DA neurons in medial and lateral VTA have distinct activity ...[more]