Ontology highlight
ABSTRACT:
SUBMITTER: Swenson SA
PROVIDER: S-EPMC7365918 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Swenson Samantha A SA Gilbreath Tyler J TJ Vahle Heather H Hynes-Smith R Willow RW Graham Jared H JH Law Henry C-H HC Amador Catalina C Woods Nicholas T NT Green Michael R MR Buckley Shannon M SM
Blood 20200701 3
Coordination of a number of molecular mechanisms including transcription, alternative splicing, and class switch recombination are required to facilitate development, activation, and survival of B cells. Disruption of these pathways can result in malignant transformation. Recently, next-generation sequencing has identified a number of novel mutations in mantle cell lymphoma (MCL) patients including mutations in the ubiquitin E3 ligase UBR5. Approximately 18% of MCL patients were found to have mu ...[more]