Ontology highlight
ABSTRACT:
SUBMITTER: Kishor A
PROVIDER: S-EPMC7367170 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kishor Aparna A Fritz Sarah E SE Haque Nazmul N Ge Zhiyun Z Tunc Ilker I Yang Wenjing W Zhu Jun J Hogg J Robert JR
Nucleic acids research 20200701 13
Alternative polyadenylation (APA) produces transcript 3' untranslated regions (3'UTRs) with distinct sequences, lengths, stabilities and functions. We show here that APA products include a class of cryptic nonsense-mediated mRNA decay (NMD) substrates with extended 3'UTRs that gene- or transcript-level analyses of NMD often fail to detect. Transcriptome-wide, the core NMD factor UPF1 preferentially recognizes long 3'UTR products of APA, leading to their systematic downregulation. Counteracting t ...[more]